I-eosinophilic esophagitis: okudingeka ukwazi

I-Eosinophilic esophagitis (i-EOE) yisifo somzimba / sokuzivikela esithinta i-esophagus - ithubhu ethatha ukudla emlonyeni wakho kuya esiswini sakho. Yize kungesona isifo esisongela impilo, kuyisimo esingelapheki esingasuki futhi okufanele silashwe kahle.

Uma une-EOE, amanani amakhulu ohlobo oluthile lweseli emhlophe yegazi - okuthiwa ama-eosinophil - atholakala kulwelwesi lwesifo sakho. Umuntu onempilo ongenayo i-EOE imvamisa akanayo ama-eosinophil akhuphukile endaweni yabo.

Ama-eosinophil ayingxenye ejwayelekile yesistimu yomzimba yokuzivikela, kepha lapho enqwabelana ku-esophagus akhipha izinto ezivuthisa ulwelwesi lweshubhu. Ngokuhamba kwesikhathi lokhu kuvuvukala nokulimala kungadala izinhlungu, ubunzima bokugwinya, noma kwandise ingozi yokudla kubhajwe emphinjeni wakho.

Mhlawumbe ngoba siyisifo esingezwani nokugula, i-EOE kwesinye isikhathi ibizwa ngokuthi 'i-oesophageal asthma'. Ngenkathi kungenzeka ukuthi kube ne-EOE ne-asthma ndawonye, ​​ziyizifo ezihlukene ezithinta izingxenye ezahlukahlukene zomzimba - i-EOE ithinta i-esophagus futhi ufuba kuthinta amaphaphu.

Ingabe i-eosinophilic esophagitis ivamile?

I-EOE ayivamile - cishe abantu abahlanu kwabangu-10,000 XNUMX bangaba nalesi simo. Kodwa-ke, izibalo zabantu abatholakala benalesi sifo ziyanda ngokushesha emhlabeni jikelele. Lokhu ngokwengxenye kungenxa yokuthi yisimo esivele sisanda kubonwa, kepha kungahle kube nezinye izizathu zokwanda.

I-EOE ijwayelekile ezinganeni nakubantu abadala kodwa ingathinta abantu banoma yimuphi ubudala. Kuvame kakhulu kubantu abaneminyaka engama-30.

Ngubani osemngciphekweni we-eosinophilic esophagitis?

Usengozini enkulu yokuthuthukisa i-EOE uma usuvele unesinye isifo sohlobo lokungezwani komzimba, njenge-asthma, eczema, hay fever, noma ukungezwani kokudla. Kungenzeka futhi ukuthi uyithuthukise uma unezihlobo ezinalesi simo. Abesilisa abaphindwe kathathu abane-EOE kunabesifazane.

Yini ebangela i-eosinophilic esophagitis?

Asazi kahle ukuthi yini ebangela i-EOE kepha kucatshangwa ukuthi kuyindlela yokuphendula omzimba ezifweni ezithile zokudla - kaningi kepha hhayi ngaso sonke isikhathi ubisi, ukolweni, amantongomane, isoya, inhlanzi namaqanda. Kungenzeka futhi ukuthi kudalwe okuthile esikuphefumulayo futhi kungahle kube nengxenye yezakhi zofuzo.

Ziyini izimpawu?

Izimpawu ze-EOE ziyahlukahluka kuye ngomuntu, kanti futhi kuya ngeminyaka yabo.

Izingane nezingane

  • Izinkinga zokondla, isb ukwenqaba ukudla noma 'ukudla okuxokozelayo'
  • Ukuhlanza kanye / noma ukuphinda wenze kabusha
  • Ukukhula okungekuhle nokuzuza kwesisindo ('ukwehluleka ukuchuma')
  • I-reflux ye-Gastroesophageal (GER), okuyilapho okuqukethwe esiswini kubuyela emuva ku-esophagus. Nge-EOE, izimpawu ze-GER azivame ukuphela nemithi.

Izingane ezindala

  • Ukuvota
  • Ubuhlungu besisu kanye / noma besifuba
  • Kunzima ukugwinya ('dysphagia'), ikakhulukazi ngokudla okuqinile
  • I-GER engajwayelekile ukuba ngcono ngemithi
  • Ukudla okungekuhle.

Abantu abadala

  • Kunzima ukugwinya, ikakhulukazi ngokudla okuqinile
  • Ukudla kunamathele emphinjeni
  • I-GER engajwayelekile ukuba ngcono ngemithi
  • isilungulela
  • Ubuhlungu besifuba.

Kuyo yonke iminyaka, izimpawu zingaholela ekulaleni okuphazamisekile.

I-Dysphagia ingazizwa sengathi ukudla okugwinyile kuya esiswini sakho kancane kakhulu noma ukunamathela maphakathi nesifuba sakho. Lokhu kungenzeka njalo uma ugwinya noma ngezikhathi ezithile. Abanye abantu bathola ukuzwa okuncane 'kokuqina', kepha kwabanye, kungahle kusuka kokungakhululeki kuye kokubi nokucindezelayo. Kungenzeka kube khona noma kungabi khona ubuhlungu ngokuzizwa.

Kwesinye isikhathi ukudla kubambeka ngokuphelele ku-esophagitis - lokhu kubizwa ngokuthi 'ukuvimbela ukudla' futhi kuyisimo esiphuthumayo kwezokwelapha.

Uma ucabanga ukuthi ungaba ne-EOE, kufanele uxoxe ngezimpawu nodokotela womndeni wakho.

Itholakala kanjani i-eosinophilic esophagitis?

Ngaphambi kokuthola ukuxilongwa, udokotela wakho uzokubuza mayelana nezimpawu zakho, umlando wezokwelapha, nokuthi ngabe wena noma amalungu omndeni wakho anakho ukungezwani komzimba okuthile. Udokotela wakho angakudlulisela kuchwepheshe ukuze enze olunye uphenyo.

Bazophinde bafune ukukhipha ezinye izimo ezingadala izimpawu zakho, njenge:

  • Isifo se-gastro-esophageal (GERD)
  • Isifo sika-Esophageal Crohn
  • Ukutheleleka (ukhunta / igciwane)
  • Isifo sokuzivikela komzimba
  • Ezinye izimbangela ezingavamile ze-eosinophilia.

I-GERD yiyona ndlela ehlukile yokuxilonga ehlukile. Abantu abaningi abaqale batholakala ukuthi bane-GERD ngemuva kwalokho batholakale bene-EOE esikhundleni salokho.

Kodwa-ke, ukuphela kwendlela yokuqinisekisa ukuxilongwa kwe-EOE ukuphenya nge-endoscopy. Lokhu kulapho ithubhu eliguquguqukayo elinekhamera encane ngakolunye uhlangothi lidluliswa ngomlomo nangomphimbo wakho emphinjeni wakho ukubuka ulwelwesi lwangaphakathi lodonga lomhosha. Ngasikhathi sinye, udokotela wakho uzothatha amasampula amathishu amancane (ama-biopsies) olwelwesi. Amasampula we-Biopsy ahlolwa ngaphansi kwesibonakhulu esinamandla amakhulu ukubala inani lama-eosinophil akhona. Ama-eosinophil angaphezu kwe-15 ngokubuka ngakunye kwemicroscope azoqinisekisa ukuxilongwa.

Uphathwa kanjani i-eosinophilic esophagitis?

Kunezinhlobo ezimbili zokwelashwa: ukwelashwa kwezidakamizwa nokuphathwa kokudla. Izinketho zezidakamizwa yilezi:

  • I-Corticosteroids - ukunciphisa ukuvuvukala. Lokhu kuvamise ukuba ngamalungiselelo oketshezi angokwezihloko owagwinyayo.
  • Iproton pump inhibitor - ukunciphisa izimpawu ze-GER nokunciphisa ukuvuvukala.

Imithi yokwelashwa ifaka phakathi ukusika ukudla okungadala izimpawu zakho ekudleni kwakho. Kubandakanya:

  • Ukuqeda ukudla - uyeka ukudla nokuphuza ukudla okuthile okuvame ukudala ukungezwani komzimba, njengobisi, ukolweni, iqanda, isoya, inhlanzi kanye ne-shellfish, amakinati namantongomane ezihlahla. Ngemuva kwamasonto ambalwa, uma izimpawu zakho ziphela, ungaphinda ukwethule ukudla ngakunye ngasikhathi
  • Ukudla okuyisisekelo - usike wonke amaprotheni esikhundleni salokho uphuze ifomula ye-amino acid. Uma izimpawu zakho ziphela uphinde ufake ukudla okwehlukene kwamaprotheni neziphuzo ngakunye
  • Ukudla okuqondiswe ekuhloleni komzimba - uqala ube ne- ukuhlolwa komzimba ukuthola ukuthi ikuphi ukudla neziphuzo ongezwani nakho. Ungabe ususika ekudleni kwakho ukuze ubone ukuthi izimpawu zakho ze-esophagitis ziyathuthuka.

Ukuphathwa kokudla kungaba enye indlela ephumelelayo ekwelashweni kwezidakamizwa, kepha akuhambelani nawo wonke umuntu - njengoba kuchaza ukunamathela emithethweni eqinile yokudla isikhathi eside ngenkathi ukhipha futhi uphinde ufake ukudla ekudleni kwakho.

Iningi labantu abane-EOE liphendula kahle ekwelashweni kwezidakamizwa noma ekwelashweni kokudla. Kodwa-ke, uma lezi zinketho zokwelashwa zingasizi ngokwanele futhi isisu sakho sinciphile, unganikezwa inqubo ebizwa nge-endoscopic esophageal dilation. Lokhu kunweba isisu ukusikhulisa, ngakho-ke kuba lula ukugwinya.

Uma ucabanga ukuthi une-EOE, kufanele ufune usizo lwezokwelapha.

 

SOURCES

I-AAAAI 2020. I-Eosinophilic esophagitis (EOE). I-American Academy of Allergy, Isifuba Somoya Ne-Immunology. https://www.aaaai.org/conditions-and-treatments/related-conditions/eosinophilic-esophagitis

KUPHELISIWE. nd. EOE. Ubambiswano lwaseMelika Lokuphazamiseka Kwe-Eosinophilic. https://apfed.org/about-ead/egids/eoe/

UDellon ES, uLiacouras CA, uMolina-Infante J et al. 2018. Kubuyekezwe Izindlela Zokuxilonga Zomhlaba Wonke ze-Eosinophilic Esophagitis: Izinqubo zeNgqungquthela EVUMILE. I-Gastroenterology 155: 1022-1033.e10. https://pubmed.ncbi.nlm.nih.gov/30009819/

U-Epstein J 2021. I-eosinophilic oesophagitis. Isifinyezo. I-BMJ Best Practice. https://bestpractice.bmj.com/topics/en-gb/1304

Amathumbu UK! nd. Izifo ze-eosinophilic. https://gutscharity.org.uk/advice-and-information/conditions/eosinophilic-diseases/#section-1

UHirano I, uKhan ES, Isikhundla MA et al. 2020. I-AGA Institute kanye ne-Joint Task Force on Allergy-Immunology Practice Parameters Guidelines Clinical for the Management of Eosinophilic Esophagitis. I-Gastroenterology 158: 1776-1786. https://www.gastrojournal.org/action/showPdf?pii=S0016-5085%2820%2930265-1

IMedline Plus 2020. I-Eosinophilic Esophagitis. https://medlineplus.gov/eosinophilicesophagitis.html

NORD / ME Rothenberg 2019. I-Esophagitis Eosinophilic. Inhlangano Kazwelonke Yezinkinga Ezingajwayelekile. https://rarediseases.org/rare-diseases/eosinophilic-esophagitis/#:~:text=Eosinophilic%20esophagitis%20(EoE)%20is%20a,the%20mouth%20to%20the%20stomach

ISurdea-Blaga T, Popovici E, Fadgyas Stănculete M, Dumitrascu DL, Scarpignato C. 2020. I-Eosinophilic Esophagitis: Ukuxilongwa nokuphathwa kwamanje. J Gastrointestin Isibindi Dis 29: 85-97. https://www.jgld.ro/jgld/index.php/jgld/article/view/768/336