Yini iSamter's Triad?

Isifo sokuphefumula esandisa i-Aspirin (i-AERD), esaziwa nangokuthi iSamter's Triad, yisimo sezempilo esiyinkimbinkimbi esihlanganisa inhlanganisela yezici ezintathu ezibalulekile - i-asthma, i-aspirin yokungezwani komzimba nama-polyp nasal. Uma ucabanga ukuthi ungaba ne-AERD noma unakekela umuntu onamandla, le ndatshana ihlola kahle ukuthi kuyini, ukuthi ukungabekezelelani i-aspirin ne-asthma kungabathinta kanjani abantu, nokuthi yiziphi izindlela zokwelashwa ezikhona.

I-AERD yisimo sokuphefumula esinezici ezintathu - isifuba somoya, ama-polyps acinanayo aphindaphindwayo, kanye nokuzwela ku-aspirin nezinye izidakamizwa ezingezona ukuvuvukala (ama-NSAID) njenge-ibuprofen, naproxen noma i-diclofenac.

Lesi simo sithola igama laso kudokotela wezifo zomzimba, uMax Samter, owasibona kuqala, kuyilapho i-'Triad 'isho izinto ezintathu ezibalulekile ezithintekayo.

Lapho abantu abane-AERD bethatha ama-aspirin noma amanye ama-NSAID, bathola ukusabela okungathandeki okubangela izinkinga zokuphefumula eziphezulu neziphansi. Ukuphendula kuvame ukwenzeka phakathi kwemizuzu engama-30-120 ngemuva kokuthatha i-aspirin futhi kungaba kubi kakhulu.

Izimpawu zokuphefumula eziphezulu zifaka:

  • Ukungqubuzana kwe-nasal
  • bekhanda
  • Ubuhlungu besono
  • Sneezing
  • Ikhala eligudlanayo noma eligobayo.
  • Ukulahlekelwa iphunga noma ukunambitha.

Izimpawu zokuphefumula ezingezansi zifaka:

  • Ukushisa
  • Ukushaya
  • Ukuqina kwesifuba
  • Ukuphefumula okunzima.

Kungaba nezinye izimpawu futhi, njengezinhlungu zesisu nokuhlanza. Abantu abangaba ngu-20% bangaphinde babhekane nokuqubuka. Abanye abantu abane-AERD nabo babhekana nokusabela okuncane okunesilinganiso esimaphakathi lapho bephuza utshwala, njengewayini elibomvu noma ubhiya.

Labo abane-AERD bavame ukuba nomlando wokutheleleka okungapheli kwesono kanye nama-polyp acinene acinene. Abanye abantu bathola ukulahleka kwephunga ngenxa yalokho futhi izimpawu zabo zingase zingaphenduli kahle ekwelashweni okuvamile.

Yini ebangela iSamter's Triad?

Asikho isizathu esisodwa esaziwayo se-AERD. Kodwa-ke, ucwaningo lukhombisile ukuthi abantu basemathubeni amaningi okuba nalo uma benesifuba somoya, izigameko eziphindaphindayo zama-polyp nasal, kanye nezifo zesono.

Akuwona wonke umuntu one-asthma ozohlakulela i-AERD. Ucwaningo lukhombisa ukuthi i-asthmatics yabantu abadala inethuba elingu-7% lokuba ne-AERD, kuyilapho abantu abane- i-asthma enamandla kukhona i-15% engaba ne-AERD. Labo abane-asthma ne-nasal polyps bangafika ku-40% kungenzeka babe nayo.

Izimpawu nezimpawu kungenzeka ukuthi ziqale ukuvela lapho abantu sebekhulile eminyakeni engama-30 nengama-40.

Itholakala kanjani iSamter's Triad?

Ukuthola ukuxilongwa okusemthethweni kwe-AERD kungaba yinkohliso, ngoba asikho isivivinyo esisodwa esingasetshenziswa ukukhomba isimo. Esikhundleni salokho, ukuxilongwa komtholampilo kwenziwa ngokususelwa enhlanganisweni yezimpawu kanye nokuphendula okwenzeka maqondana ne-aspirin noma amanye ama-NSAID. Ngezinye izikhathi kungathatha isikhathi ukuqeda ezinye izimbangela kuqala.

Uma ungenaso isiqiniseko sokuthi ngabe uke wasabela ku-aspirin, inqubo esemthethweni yokuphonsela inselelo i-aspirin ingenziwa ngaphansi kokuqondisa kwezokwelapha ukuhlola ukusabela kwakho. Lolu uhlobo lokucasulwa kwezidakamizwa lapho ochwepheshe bezokwelapha bezonikeza iziguli imithamo elawulwayo yomuthi abazwela kakhulu kuwo, ukuqapha ukusabela kwabo nokwakha ukuxilongwa okugcwele.

Ingabe i-AERD isongela impilo?

I-AERD yisifo esingelapheki esingadala izimpawu eziqhubekayo. Lezi zimpawu zingaba nzima, zithinte ikhwalithi yempilo yalabo abane-AERD, futhi ukuthola inhlanganisela efanelekile yokwelashwa kungaba yinselele.

I-asthma ingenye yezinto ezintathu eziyinhloko ze-AERD. I-asthma enamandla engalawulwa kahle, noma engaphenduli kahle ekwelashweni, ingasongela impilo. Lesi ngesinye sezizathu esenza noma ngubani one-AERD adinge ukulandela okuphethwe kahle ukwelapha isifo se-asthma ukuhlela. ??? (idinga ukuvuselelwa)

Ukudla kungayithinta kanjani iSamter's Triad?

Ukuphuza utshwala kungathinta labo abane-AERD. Abanye abantu, ngokwesibonelo, batholakale bethola ukusabela lapho bephuza utshwala obufana newayini elibomvu noma ubhiya, ngakho-ke ukunciphisa ukusetshenziswa kotshwala kungaba lusizo.

Isazi se-Immunologist uMax Samter ekuqaleni wayecabanga ukuthi izimpawu ze-AERD zingaqhubeka ngenxa yokusetshenziswa kwama-salicylates ekudleni. Ezinye izifundo zihlolisise izinzuzo zokudla okuncane kwe-salicylate futhi zathola ukuthi zingathuthukisa izimpawu zamakhala kulabo abane-AERD. Kodwa-ke, ubufakazi abuphelele futhi kudingeka olunye ucwaningo ukusekela le mbono, ikakhulukazi njengoba ukudla okuphansi kwe-salicylate kuhilela ukusika ukudla okuningi okunempilo nokunomsoco, njengezithelo nemifino, okunemikhawulo futhi okungafanele impilo yakho yonke .

Esikhundleni salokho, abanye ochwepheshe basikisela ukuthi ukudla okune-omega-6 fatty acids ephezulu kanye ne-omega-3 fatty acids kungafaneleka kakhulu ku-AERD. Ukucwaninga ngezinzuzo zokuncipha kokusetshenziswa kwama-omega-6 fatty acids kube nemiphumela emihle. Njengoba abantu abane-AERD bevame ukuba namazinga aphezulu ama-cysteinyl leukotrienes ne-prostaglandin D2 (i-lipids yokuvuvukala), etholakala ekusetshenzisweni komzimba we-omega-6 fatty acids, ukunciphisa lawa ma-acid kungasiza. Imiphumela yocwaningo ibonise ukuthi lokhu kuncishiswa kuthuthukise izimpawu zesinus nokulawulwa kwesifuba somoya. Kodwa-ke, kufanele uhlale uthintana nodokotela ngaphambi kokushintsha indlela odla ngayo - bangakunikeza iseluleko nendlela engcono yokwenza lokho futhi bancome uma kuwumbono omuhle kuwe.

Ingabe iSamter's Triad autoimmune?

Ngenkathi ucwaningo ku-AERD luqhubeka, okwamanje aluthathwa njengesimo sokuzimela. Ngezifo ezizimele, amasosha omzimba ahlasela izicubu emzimbeni - lokhu akukholakala ukuthi kwenzeka nge-Samter's Triad.

Esikhundleni salokho, iSamter's Triad ithathwa njengesifo esisekelwe ukuhlukunyezwa okungapheli komzimba.

Ucwaningo lukhombisile ukuthi abantu abane-AERD bavame ukuba namazinga aphezulu ama-eosinophil kuma-polyps abo acinene namazinga aphezulu ama-eosinophil egazini labo. Ama-Eosinophil amangqamuzana omzimba axhumene nokuvuvukala futhi angaholela ekuvukeleni okungapheli ezindleleni zomoya.

Kutholakale nokuthi abantu abane-AERD banezinkinga ze-cyclooxygenase enzyme (COX) futhi bakhiqiza amazinga aphezulu ama-leukotrienes - noma ama-molecule wokuvuvukala. Amaleveli ama-leukotrienes akhuphuka uma i-aspirin ithathwa, kuphakamisa ukuthi i-AERD inesici sesifo sokuvuvukala.

Yikuphi ukwelashwa okukhona kwe-AERD?

Iningi labantu abane-AERD lizodinga ukusebenzisa imithi nsuku zonke ukubhekana nokuphatha izimpawu zabo. Kunezindlela zokwelashwa ezahlukahlukene ezikhona ezivame ukunconywa ngokuhlangana nomunye - ningaxoxa ngezindlela ezingcono kakhulu ongazidingida nodokotela wakho womndeni noma uchwepheshe.

Ukuphatha izimpawu ze-asthma

Noma ngubani one-AERD kumele aphathe eyakhe izimpawu ze-asthma nsuku zonke, ngokuthatha imishanguzo enqunyiwe ye-corticosteroid, njenge-preventer ne-reliever inhalers.

I-Steroids

Ukuvuvukala kwe-Sinus kungalawulwa ngokusetshenziswa kwe-intra-nasal steroid sprays kanye ne-rinses ye-steroid. Ama-steroids omlomo angadingeka ngezikhathi ezithile ukwelapha ama-polyp nasal.

Ukuhlinzwa ngamakhala

Ukuhlinzwa emakhaleni kungasetshenziswa ukususa ama-polyps anenkinga. Kodwa-ke, bavame ukukhula emuva, ngakho-ke lesi akusona isixazululo sesikhathi eside.

Ukwelashwa kokuhlehla

Ukwelashwa kwe-De-sensitization kungasetshenziselwa ukuthuthukisa ukubekezelelana komuntu ku-aspirin. Le ndlela ibaluleke kakhulu kunoma ngubani odinga ukuthatha i-aspirin ngenxa yesifo senhliziyo noma ubuhlungu obungapheli. Kwabanye abantu, ukungafuneki kwemvelo kungathuthukisa izimpawu zesifuba somoya, kunciphise ama-polyp nasal futhi kunciphise ukuvuvukala kwesono.

Ukugwema i-aspirin

Kwabanye, ukugwema i-aspirin nezinye izidakamizwa ze-NSAID kuyindlela engcono yokunciphisa ubungozi bokusabela okwenzekayo. Kodwa-ke, kungaba nzima ukugwema yonke le mithi ngokuphelele njengoba ijwayele ukunikezwa ezinye izimo.

Izifo

Imijovo ye-Biologic ingasiza abantu abane-asthma elinganiselayo nama-polyp nasal. I-Biologics wuhlobo lomuthi owenziwe noma oqukethe imithombo yezinto eziphilayo ezisiza ukuvimbela ukuvuvukala.

Uma ucabanga ukuthi ungaba ne-AERD, kufanele ukhulume nodokotela ongakunikeza izeluleko.  

 

Imithombo

I-Aspirin Yandisa Izifo Zokuphefumula

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Umphakathi weSamter

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