Umhlangano Wesayensi Obonakalayo

Isifinyezo Somhlangano We-GAAPP 2020

Sibonga bonke abangabamba iqhaza emhlanganweni wethu wesine wesine ngoJuni 4 ngqo.
Kubo bonke abangenalo ithuba lokubamba iqhaza emhlanganweni cishe sinikeza amafayela alalelwayo anamathiselwe.

Nasi isifinyezo esifushane somnikelo wesipikha ngasinye.

Sinezikhulumi ezine ezinhle kakhulu ebezikhuluma ngezindaba ezinezihloko eziphezulu kakhulu.

  • USolwazi Ioana Agache, uMongameli Owedlule we-EAACI
  • UProfesa Tobias Welte, uMongameli Wangaphambilini u-ERS
  • UPatrice Becker MD, oyiNhloko Yesigaba, i-Ashtam ne-Airways Biology, i-NIAID / DAIT / AAABB
  • UProfesa Andrew Menzies-Gow, Uchwepheshe We-Asthma Omkhulu kanye noMqondisi woMtholampilo Kazwelonke weNHS England Wezinsizakalo Zokuphefumula

UProf. Agache: “Imihlahlandlela ye-EAACI: Isifuba Somoya Esibangelwa Uthuthuva LweNdlu”

https://onlinelibrary.wiley.com/doi/epdf/10.1111/all.13749

o Izingane ezingama-85% ezine-asthma zinezifo ezingezwani nomzimba
o Ukungezwani komzimba ne-HDM kubantu abadala abangama-20-40% abane-asthma
o Model 1 vs Model 2 ndlela
o Vuselela imihlahlandlela ye-AIT:

  • Amathebulethi we-HDM - Izincomo ezilinganiselwe Abantu abadala
  • Ama-HDM Drops - Izincomo eziphansi Abadala nezingane
  • I-HDM SCIT - Izincomo eziphansi Abadala nezingane

Ukuvimbela izingane ezine-AE noma umlando oqinile we-atopic-yebo-kungathuthukisa ukusebenza kwamaphaphu ezindleleni ezincane zomoya

UProf. Agache: “Izincomo Zokusetshenziswa Kwama-Biologicals ku-Asthma Eqatha”

https://onlinelibrary.wiley.com/doi/epdf/10.1111/all.14235

Ukwelashwa nge-Biologic (i-benralizumab, i-dupilumab ne-omalizumab) kuzothathwa isinqumo nge-phenotype ne-endotype (kuya ngama-biomarkers kanye
ama-comorbidities)
o Ukwenza izinqumo ngokuhlanganyela kudlala indima enkulu ekukhetheni ukwelashwa kwaseNingizimu Afrika
> I-Phenotype + Biomarker + Isinqumo Esenziwe Ngomphumela Ekwenziweni Kwezinqumo phakathi kweziguli ne-HCP
> Qalisa isilingo sezinyanga ezi-3 uphinde uhlole impendulo
o Sicela uhlole isilayidi se-Biomarker ne-Comorbidity slide!

UProf. Welte: “Izifo Zokuphefumula kanye COVID-19"
Ubike ngesixhumanisi esithokozisayo esiya e-Italy Fashion Week futhi wasabalala kusuka eChina kanye nokusabalala okukhulu kusuka endaweni yase-Austrian ski Ischgl kuya ezimweni eziningi zase-Iceland.
Ukusabalala kwezifo ngenxa yoSuku 5 ngaphambi kwezimpawu nokuhlolwa kwe-PCR ezinsukwini zokuqala ezinhlanu Ukuqhubekela phambili okungekuhle kwe COVID - Usuku lwe-14 luyisihluthulelo - ukululama noma ukuqhubekela phambili ku-ARDS
Ukukhathala uphawu oluphawuleka kakhulu lokuthunyelwa kwamasonto COVID
Ama-angiogenesis ancike kumaseli athintekile. COVID-19 yisifo se-endothelial; umkhuhlane
kuthinta i-epithelial
Ama-comorbidities: Inhliziyo nemithambo yegazi ivame kakhulu ukubhekana nenkinga
- Isifuba Somoya 9% &
- I-COPD 5%
- Umfutho wegazi ophezulu 56%
- Isifo sikashukela 32%
Ukwelashwa: I-Heparin yazo zonke iziguli - zonke ezinye izindlela zokwelapha ziyahlolwa
Ukuqedwa kwe-EOS? UWelte wayeneziguli ku-biologics nge COVID
I-High eNO High ICS / LABA
Akukho ukutheleleka kwesibili okubonwayo okwamanje

UProf. Becker: NIH / NIAID
Isikhungo sakhe senza izifundo ezimbili mayelana:

  • Ukungezwani komzimba nesifo somoya COVID ukufunda: ngaphakathi kwemindeni ye-2000; ukuthumela esibhedlela
    isifundo, okuthunyelwe konyaka ongu-1 COVID
  • Izinguquko emasosheni omzimba: Amasiginesha ama-immune alabo abane-
    ubunzima vs labo abangakwenzi

o Isenzo Sokulashwa Kokwelashwa — Remdesivir vs Remdesivir + //// Umuthi wokugoma weMederna Isigaba I
o Umuthi wokugoma ongahle utholakale ngo-2021 noma kamuva; Ukwelashwa kungenzeka ngasekupheleni kuka-2021-2022
Ukubandakanyeka Kweziguli ku-R & D — PFDD, Abameli Beziguli, Amabhodi Ezikhangiso, ukwenziwa kwecala
o Indlela yomoya ehlanganisiwe yokuma COVID ngokuhamba kwamakhala ngaphambi kokungena emaphashini

UProfesa Menzies-Gow: Ikusasa Lesifuba Somoya Esibi - Ukuthuthukisa Isayensi
o Iziguli zesifo somoya ezingama-48% azikaze zibone uchwepheshe
o> Ama-50% wezindleko zokunakekelwa kwezempilo ezihlobene nesifuba ezibangelwa yi-10% yabantu be-asthma
o I-Epithelium ibonakala iyinzwa yokhiye yemvelo yangaphandle; amafomu
umgoqo wokuvikela; ikhiqiza ama-cytokines
o AmaCytokines abangela inqubo yokuvuvukala esezansi
o I-TSLP, IL33, IL25 iphazamisa ekuqaleni kwe-cascade
Ezinye iziguli zifuna ukuthethelelwa kwesifuba somoya okuphelele
o Ukuphatha kwe-OCS; I-17% OCS rx nge-PUD (kufanele yenze kangcono inikezwe uhlangothi lwesikhathi eside
imiphumela ye-OCS!)

Landa Isifinyezo: